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3-beta-hydroxysteroid-Delta (EBP), Human, ELISA Kit

3-beta-hydroxysteroid-Delta (EBP), Human, ELISA Kit, CSB-EL007363HU | ARP American Research Products, Inc.

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Product Code: CSB-EL007363HU

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Product Details Protocol
Product Code: CSB-EL007363HU
Product Name:3-beta-hydroxysteroid-Delta (EBP), Human, ELISA Kit
Background:This protein is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Antigen Name:Emopamil binding protein (sterol isomerase)
Synonyms:CDPX2, CHO2, CPX, CPXD, 3-beta-hydroxysteroid-delta-8,delta-7-isomerase, Chondrodysplasia punctata-2, X-linked dominant (Happle syndrome), emopamil-binding protein (sterol isomerase), sterol 8-isomeras
Sample Types:Serum, Plasma, Tissue Homogenates, Cell Lysates
Detection Range:15.6 pg/ml-1000 pg/ml
Sensitivity:3.9 pg/ml
Interest Field:Biosynthesis/Metabolism
Intended Use: For Research Use Only.

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