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4-1BB Receptor, Human, Recombinant




 

Our Price: $99.00

Product Code: 28-10069


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5 µg
20 µg [Add $100.00]
1 mg [Add $3,000.00]

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Product Details
 
Product Code:28-10069
Product:4-1BB Receptor, Human, Recombinant
Description:4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.
Synonyms:TNFRSF9, CD137 antigen, T-cell antigen ILA
AA Sequence:MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS
Source:E. Coli
Purity:98%
Biological Activity:Determined by its inhibitory effect of the 4-1BBL mediated stimulation of IL-8 production by human PBMC. About 90% of inibition was seen using a concentration of 1ug for both 4-1BBL and 4-1BBR.
Cross Reactivity:NULL
Endotoxin Level:Endotoxin level is <0.1 ng/ug of protein (<1EU/ug).
Protein Content:Verified by UV Spectroscopy and/or SDS-PAGE gel.
Authenticity:Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Interest Fields:Apoptosis, Proliferation, Receptors, TNF Superfamily
Storage:Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

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