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4-1BB ligand, 71-254aa, Human, His-tagged, Recombinant, E.coli




 

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Product Code: 01-2073


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20 µg
100 µg [Add $190.00]
0.5 mg [Add $670.00]

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Product Details
 
Product Code:01-2073
Product:4-1BB ligand , 71-254aa, Human, His-tagged, Recombinant, E.coli
Description:4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease. Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Synonyms:Tumor necrosis factor ligand superfamily member 9, TNFSF9, 4-1BBL, CD137L, 4-1BB ligand, 4 1BB L, 4 1BB ligand, 4 1BBL, Cd137l, Cd157l, homolog of mouse 4 1BB L, homolog of mouse 4 1BBL, ILA ligand (TNF related), Ly63l, receptor 4 1BB ligand, Tumor necrosis factor (ligand) superfamily member 9.
NCBI Number:NP_003802
Antigen Species:Human
Applications:SDS-PAGE
Form:Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 100mM NaCl, 20% glycerol
Concentration:1 mg/ml (determined by Bradford assay)
Purity:> 95% by SDS - PAGE
Molecular Weight:23.8 kDa (222aa), confirmed by MALDI-TOF.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMRE GPELSPDDPA GLLDLRQGMF AQLVAQNVLL IDGPLSWYSD PGLAGVSLTG GLSYKEDTKE LVVAKAGVYY VFFQLELRRV VAGEGSGSVS LALHLQPLRS AAGAAALALT VDLPPASSEA RNSAFGFQGR LLHLSAGQRL GVHLHTEARA RHAWQLTQGA TVLGLFRVTP EIPAGLPSPR SE
Gene Category:Hormones & Cytokines
Storage:Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References:
  • Lee SW., et al. (2008). Nat Immunol. 9(8):917-26
  • Sharma RK., et al. (2009). Cancer Res. 69(10):4319-26
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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