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ABAT Polyclonal Antibody




 

Our Price: $130.00

Product Code: A5299


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Product Details
 
Product CodeA5299
Product:ABAT Polyclonal Antibody
Background:4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Category:Polyclonal Antibody
Species:Rabbit
Synonyms:GABAT, NPD009, GABA-AT
Immunogen:Recombinant protein of human ABAT
Isotype:IgG
Molecular Weight:56kDa
Purity:Affinity purification
Form:Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Reactivity:Human, Mouse, Rat
Applications:WB, IHC, IF
Working Dilutions:WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
GeneID:18
SwissProt:P80404
Storage:Store at -20C. Avoid freeze/thaw cycles.
Image Description:Western blot analysis of extracts of various cell lines, using ABAT antibody.|Immunohistochemistry of paraffin-embedded rat kidney using ABAT antibody at dilution of 1:100 (x40 lens).|Immunohistochemistry of paraffin-embedded human liver injury using ABAT antibody at dilution of 1:100 (x40 lens).|Immunohistochemistry of paraffin-embedded human gastric cancer using ABAT antibody at dilution of 1:100 (x40 lens).|Immunofluorescence analysis of A549 cell using ABAT antibody. Blue: DAPI for nuclear staining.
Research Area:Cancer, Neuroscience, Cell Biology, Metabolism, Amino Acids,
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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