Home > Suppliers > ABclonal >

ABCB1 Polyclonal Antibody




 

Our Price: $130.00

Product Code: A1284


Size*:
50 µl
100 µl [Add $90.00]
200 µl [Add $250.00]

Qty:
Product Details
 
Product CodeA1284
Product:ABCB1 Polyclonal Antibody
Background:MDR1/ABCB1 belongs to the Mdr/Tap subfamily of the ATP binding casette transporter superfamily (1). MDR1 serves as an efflux pump for xenobiotic compounds with broad substrate specificity. Its substrates include therapeutic agents, such as actinomycin D, etoposide, imatinib, and doxorubicin, as well as endogenous molecules, such as _-amyloids, steroid hormones, lipids, phospholipids, cholesterol, and cytokines (2). Research studies have shown that MDR1 reduces drug accumulation in cancer cells, allowing the development of drug resistance (3-5). On the other hand, MDR1 expressed in the plasma membrane of cells in the blood-brain, blood-cerebral spinal fluid, or blood-placenta barriers restricts the permeability of drugs into these organs from the apical or serosal side (6,7). MDR1 is also expressed in normal tissues with excretory function such as small intestine, liver, and kidney (7). Intracellular MDR1 has been detected in the ER, vesicles, and nuclear envelope, and has been associated with cell trafficking machinery (8). Other reported functions of MDR1 include viral resistance, cytokine trafficking (9,10), and lipid homeostasis in the peripheral and central nervous system (11-13).
Category:Polyclonal Antibody
Species:Rabbit
Synonyms:Multidrug resistance protein 1, ABCB1, MDR1, PGY1
Immunogen:Recombinant protein of human ABCB1
Isotype:IgG
Molecular Weight:141kDa
Purity:Affinity purification
Form:Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Reactivity:Human, Mouse
Applications:WB
Working Dilutions:WB 1:500 - 1:2000
GeneID:5243
SwissProt:P08183
Storage:Store at -20C. Avoid freeze/thaw cycles.
Image Description:Western blot analysis of extracts of various cell lines, using ABCB1 antibody.
Research Area:Cancer, Stem cells, Metabolism,
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

Share your knowledge of this product. Be the first to write a review »