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ABCC2 Polyclonal Antibody




 

Our Price: $130.00

Product Code: A8405


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Product Details
 
Product CodeA8405
Product:ABCC2 Polyclonal Antibody
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Category:Polyclonal Antibody
Species:Rabbit
Synonyms:DJS, MRP2, cMRP, ABC30, CMOAT,
Immunogen:Recombinant protein of human ABCC2
Isotype:IgG
Molecular Weight:174kDa
Purity:Affinity purification
Form:Liquid, in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Reactivity:Human
Applications:WB
Working Dilutions:WB 1:500 - 1:2000
GeneID:1244
SwissProt:Q92887
Storage:Store at -20C. Avoid freeze/thaw cycles.
Image Description:Western blot analysis of extracts of various cells, using ABCC2 antibody.
Research Area:Cancer, Metabolism,
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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