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ATG4D Polyclonal Antibody: RPE




 

Our Price: $339.00

Product Code: 32P-635D-RPE


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100 µg

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Product Details
 
Product Code32P-635D-RPE
Product:ATG4D Antibody: RPE
Description:Rabbit Anti-Human ATG4D Polyclonal
Background:ATG4D, Auotphagy related 4D, cysteine peptidases, belong to the autophagy-related protein 4 family of C54 endopeptidases. Members of this family play a role in the biogenesis of autophagosomes (1). Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (2).
Target:ATG4D
Conjugate:RPE
Synonyms:Autophagin-4 Antibody, APG4D Antibody, ATG4D Antibody, Cysteine protease ATG4D Antibody, AUTL4 Antibody, Autophagy-related cysteine endopeptidase 4 Antibody, EC:3.4.22.- Antibody, AUT-like 4 cysteine endopeptidase Antibody, Autophagy-related protein 4 homolog D Antibody,
Product Category:Polyclonal Antibodies
Immunogen:Synthetic peptide from the N-terminal of Human ATG4D (aa. 98-108)
ApplicationsWB, ICC/IF
HostRabbit
Reactivity:Human
Working Dilution:WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Form:Purified, in PBS, 50% glycerol, 0.09% sodium azide
Concentration:1 mg/ml
Specificity:Detects ~53 kDa.
Accession #:NP_001268433.1
Gene ID:84971
SwissProt:Q86TL0
Storage:-20_C
Cellular Localization:Cytoplasm
Research Area:Cardiovascular System, Heart, Cancer, Autophagy
References:1. "Entrez Gene: Autophagy related 4D, cysteine peptidase". 2. Li M., et al. (2011) J Biol Chem. 286: 7327-7338.
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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