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ATG5 Polyclonal Antibody: ATTO 594




 

Our Price: $349.00

Product Code: 32P-612D-A594


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100 µg

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Product Details
 
Product Code32P-612D-A594
Product:ATG5 Antibody: ATTO 594
Description:Rabbit Anti-Human ATG5 Polyclonal
Background:ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (1). Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. ATG5 is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II (2).
Target:ATG5
Conjugate:ATTO 594
Synonyms:APG5-like Antibody, ASP Antibody, hAPG5 Antibody
Product Category:Polyclonal Antibodies
Immunogen:Synthetic peptide from the N-terminal of human ATG5
ApplicationsWB, ICC/IF
HostRabbit
Reactivity:Human
Working Dilution:WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Form:Purified, in PBS, 50% glycerol, 0.09% sodium azide
Concentration:1 mg/ml
Specificity:Predicted molecular weight at ~32.4kDa. Observed molecular weights at ~48-60kDa based on ATG12-ATG5 heterodimer.
Accession #:NP_001273035.1
Gene ID:9474
SwissProt:Q9H1Y0
Storage:-20_C
Cellular Localization:Cytoplasm
Research Area:Cancer, Apoptosis, Cancer, Autophagy, Cardiovascular System, Heart, Cell Signaling, Metabolism, Metabolism processes
References:1. Pyo J.O., et al. (2005) J Biol Chem. 280(21): 20722-20729. 2. Mizushima N., et al. (2003) Mol Biol Cell. 15(3): 1101-1111.
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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