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Alpha-2-macroglobulin




 

Our Price: $109.00

Product Code: 13-3010


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100 µg

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Product Details
 
Product Code:13-3010
Product:Alpha-2-macroglobulin
Description:A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.
Background:Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.
Synonyms:A2M, A2MD, CPAMD5, FWP007, S863-7
Source:
  • Human plasma. Blood sample from donors was tested and found negative
  • for HBsAg, HIV-1&2 antibodies, HCV and Syphilis
Molecular Weight:725000
Purity:
  • Greater than 95% determined by SDS-PAGE. Cellulose acetate electrophoresis shows the major product to have alpha-2 mobility.
  • Protein determination by the method of Lowry and
  • Polyacrylamide gradient gel electrophoresis shows
  • one band only corresponding the molecular weight
  • of Alpha-2-macroglobulin.
Form:
  • Purified protein, in 30 mM Na Phosphate, pH 7.0 , with glycine as a stabilize
  • and 0.1% sodium azide.
Storage:2-8C for immediate use, or at -20C (aliquot)
Notes:Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens.
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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