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Anti-Adeno-associated virus (AAV2), intact particles, A20, Supernatant Concentrate

Anti-Adeno-associated virus (AAV2), intact particles, A20, Supernatant Concentrate


Our Price: $209.00

Product Code: 03-65255

25 µl

Product Details References
Product Code: 03-65255
Product: Anti-Adeno-associated virus (AAV2), intact particles, clone A20, Supernatant Concentrate
Description: For characterization of different stages of infection and very useful for the analysis of Specificity the AAV2 assembly process. A20 specifically reacts with intact adeno-associated virus 2 particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins. The antibody cannot be used for immunoblotting. Epitope mapping experiments (Wobus, C. E. et al., 2000 ) identified four immunoreactive (discontinous) regions. The major reaction was attributed to sequence aa 369 to aa 378 of AAV2 capsids. The antibody is also useful for neutralizing experiments (Moskalenko, M. et al., 2000).
Category: Mouse monoclonal
Clone: A20
Ig Subtype: IgG3
Background: Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Synonyms: AAV2
Immunogen: Adeno-associated virus 2 capsid proteins and virus particles
Form: Hybridoma cell culture supernatant concentrate, contains 0.09% sodium azide
Reactivity: AAV-2, AAV-3
Specificity: Specifically detects intact virus particles, both empty and full capsids. With AAV-2 and AAV-3 A20 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not for WB.
Applications: Immunofluorescence microscopy, Immunohistochemistry, Immunoprecipitation, Affinity chromatography, ELISA
Working Dilution: Optimal dilution should be determined by the end user.
Storage: 2-8C for immediate use, or at -20C (aliquot)
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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