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Anti-Adeno-associated virus type 5 (AAV-5), intact particles, Supernatant Concentrate




 

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Product Code: 03-652148


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100 µl

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Product Details
 
Product Code:03-652148
Product:Anti-Adeno-associated virus type 5 (AAV-5), intact particles, Supernatant Concentrate
Description:Mouse Monoclonal Antibody to Adeno-Associated Virus, serotype 5 (AAV-5), intact particles. Specifically detects intact virus particles, both empty and full capsids. ADK5a recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting.
Category:Mouse monoclonal
Clone:ADK5a
Ig Subtype:IgG2a, kappa
Background: Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Synonyms:AAV5
Immunogen:Adeno-associated virus type 5 (AAV-5) capsid proteins and virus particles
Form:Hybridoma cell culture supernatant concentrate, contains 0.09% sodium azide
Reactivity:AAV-5 found in human & monkey
Specificity:For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK5a specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins.
Applications:Immunofluorescence microscopy, Immunohistochemistry, Immunoprecipitation, Affinity chromatography, ELISA
Working Dilution:
  • 1:100 for Immunohistochemistry
Storage:2-8C for immediate use, or at -20C (aliquot)
References:Tseng, Y.-S. et al. Adeno-Associated Virus Serotype 1 (AAV1)-and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity. J. Virol. 89, 1794–1808 (2015).

Mietzsch, M. et al. OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy. Hum. Gene Ther. 25, 212–222 (2014).

Kuck, D et al. (2007) Virol Methods 140: 17-24
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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