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Anti-Adeno-Associated Virus (AAV), Rep Protein, clone 226.7




 

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Product Code: 03-65172


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1 ml

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Product Details
 
Product Code:03-65172
Product:Anti-Adeno-Associated Virus (AAV), Rep Protein, clone 226.7
Description:Mouse Monoclonal Antibody to Adeno-Associated Virus (AAV), Rep Protein. Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in AAV-infected cells. In Immunoblotting prominant reaction with Rep 78 and Rep 68, only faint reaction with Rep 52 and Rep 40.
Category:Mouse monoclonal
Clone:226.7
Ig Subtype:IgG1
Background: Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Immunogen:Rec.AAV-2 Rep 78 protein, N-terminally truncated by 171 aa
Form:Hybridoma culture supernatant
Reactivity:AAV-2, found in human and monkey
Specificity:Mab 226.7 reacts with Rep proteins (Rep78, Rep68, Rep52 and Rep40) of human AAV-2-infected cells. The antibody shows low affinity which is most useful in affinity chromatography experiments where mild conditions can be used for dissociation of the antigen. In immunoblotting it reacts mainly with Rep52 and Rep40, faint reaction with Rep78 and Rep68 (long incubation time and short wash- ing steps are recommended). Alternatively for immunoblotting cat. nos. 03-61069 /03-65169 and 03-61071 /03-65171 and for immunofluorescence micros- copy cat. nos. 03-61073/03-65173 are suggested.
Applications:Immunoaffinity chromatography, Immunoprecipitation, Immunoblotting (see restrictions under specificity), Immunofluorescence microscopy (only faint reaction)
Working Dilution:1:2 for immunoblotting; dilute further when using ECL method
Storage:2-8C
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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