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Anti-Adeno-associated virus type 1 (AAV-1), intact particles, Biotin




 

Our Price: $109.00

Product Code: 03-615150


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100 µl

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Product Details
 
Product Code:03-615150
Product:Anti-Adeno-associated virus type 1 (AAV-1), intact particles, Biotin
Description:Mouse Monoclonal Antibody to Adeno-Associated Virus, serotype 1 (AAV-1), intact particles. Specifically detects AAV-1 intact virus particles, both empty and full capsids. ADK1a recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not suitable for Immunoblotting. In immunofluorescence, a week cross-reactivity was observed with AAV-6. No reaction with AAV type 2, 3, 4, 5.
Category:Mouse monoclonal
Clone:ADK1a
Ig Subtype:IgG2a, lambda
Background: Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Immunogen:Adeno-associated virus type 1 (AAV-1) capsid proteins and virus particles
Form:Biotin conjugated, 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4
Reactivity:AAV1 (weak cross-reaction with AAV6)
Specificity:For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK1a specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins.
Applications:Immunohistochemistry, ELISA. This antibody cannot be used for immunoblotting.
Working Dilution:
  • 1:20 for ELISA
Storage:2-8C
References:Kuck, D et al. (2007) Virol Methods 140: 17-24

Mietzsch, M. et al. OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1–12 Vectors for Gene Therapy. Hum. Gene Ther. 25, 212–222 (2014).
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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