Polyclonal antibodies (PAbs) are powerful biological
tools that are used in the analysis of antigens in a wide variety of research
and in vitro diagnostic applications.
Traditionally, polyclonal antibodies are raised in large animals such as goats
and rabbits. The immunized animal produces an antibody response that is
heterogeneous in nature and the serum harvested recognizes multiple antigenic
epitopes. Polyclonal antibodies can be generated more rapidly than monoclonal
antibodies (MAbs) and consequently a vast number of polyclonal antibodies have
been developed against a wide range of biological targets. In recent years, the use of affinity
purification has improved the quality and performance of polyclonal antibodies.
Like Monoclonal antibodies, PAbs are used in a wide variety of applications
including western blotting, Enzyme linked immunosorbent assays (ELISA), immunohistology
and immunoprecipitation techniques. Polyclonal antibodies are more stable than
MAbs over a broad pH and are therefore more suitable for pH sensitive applications.
ARP American Research Products provides an
extensive range of internationally recognised polyclonal antibodies. The product range includes high quality antibodies, designed
for research use, against biological targets that are of potential diagnostic
and therapeutic interest.
Polyclonal antibodies recognizing
The complement system consists of a specific
group of proteins that play a pivotal role in the innate immune response,
inflammation and homeostasis. In response to the recognition of a potential
pathogen, inactive complement proteins interact with each other in an enzymatic
cascade and become sequentially activated. Protein fragments are generated
during this process that act as chemo-attractants, adhesion molecules and
opsonins. The complement system can be activated via three different pathways
1) Classical pathway 2) alternative pathway 3) Mannose binding lectin pathway.
ARP American Research Products supplies a wide
range of polyclonal antibodies that recognize key components of the complement
system including C1q and Cd4.
anti human C4d
Rabbit anti human C4d: Ready-to-use
anti C1q conjugated to FITC
Polyclonal anti p62 protein
The p62 protein, also known as sequestosome
1, is encoded by the SQSTM1 gene. It is an adaptor protein that binds ubiquitin
and is involved in bone remodelling and various cellular processes. P62 also acts
as an autophagy receptor that is required for the formation and degradation of
ARP supplies a range of polyclonal antibodies
recognizing the p62 protein including a guinea pig polyclonal against the
C-terminal region of p62.
Rabbit anti p62
Guinea pig anti p62 (C-terminal)
Polyclonal antibodies recognizing Adeno-associated
Adeno-associated viruses A(AAV), from the
parvovirus family, are small single-stranded DNA viruses that affect humans and
some additional primate species. AAV are currently considered to be
non-pathogenic and most people infected with AAV only develop a mild immune
response. Adeno-associated viruses carry genes into both dividing and quiescent
cells where they can insert genetic information into the host genome These
characteristics of AAV have been exploited for gene therapy and AAV virus have
been engineered to carry therapeutic genes into host cells.
A range of polyclonal antibodies are available from ARP which recognize intact
AAV particles and capsid proteins VP1, VP2 and VP3.
Rabbit anti Adeno-associated virus (AAV) VP1, VP2, VP3