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Bovine Collagen alpha-1 (XVIII) chian (COL18A1) ELISA Kit

Bovine Collagen alpha-1 (XVIII) chian (COL18A1) ELISA Kit


 
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Product Code: KTE10433


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Product Details
 
Product CodeKTE10433
Product:Bovine Collagen alpha-1 (XVIII) chian (COL18A1) ELISA Kit
Description:This Bovine Collagen alpha-1 (XVIII) chian (COL18A1) ELISA Kit employs a two-site sandwich ELISA to quantitate COL18A1 in samples. An antibody specific for COL18A1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyCOL18A1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for COL18A1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of COL18A1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Species:Bovine
Background:Collagen, type XVIII, alpha 1, also known as COL18A1,alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains.The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:COL18A1, FLJ27325, FLJ34914, KNO, KNO1, MGC74745, alpha 1 type XVIII collagen, antiangiogenic agent, endostatin, multi-functional protein MFP
Detection Method:Colorimetric
Sample Type:Cell culture supernatants, Serum, Plasma, Other biological fluids
Assay Type:Sandwich ELISA (quantitative)
Intended Use:For Research Use Only
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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