14-3-3 eta, 1-246aa, Human

Proteins, Recombinant
More Information
Product Name 14-3-3 eta, 1-246aa, Human
Background 14-3-3 eta also as known as YWHAH. This protein belong to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 eta interacts with and relocalizes the A20 zinc finger protein from the insoluble to the soluble fraction, suggesting a chaperone function. It implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binding to a large number of partners, usually by recognition of a phosphothreonine motif. Recombinant Human 14-3-3 eta was expressed in E.coli and purified by using conventional chromatography techniques.
Species Human
Synonyms YWHAH, YWHA1
Host E.coli
AA Sequence MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIE
KELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS
VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN
Molecular Weight 21.8kDa (192aa)
28-40kDa (SDS-PAGE under reducing conditions)
Form Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Concentration 0.5mg/ml (determined by Absorbance at 280nm)
Purity > 90% by SDS-PAGE
Applications SDS-PAGE
NCBI NP_003396
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Maksymowych WP., et al. (2014) Arthritis Res Ther. 16(2): R99.
Sato S., et al. (2002) J Biol Chem. 277: 39360-39367

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