4-1BB ligand, 71-254aa, Human, Recombinant

Proteins, Recombinant
More Information
Product Name 4-1BB ligand, 71-254aa, Human, Recombinant
Background 4-1BB ligand is a type 2 transmembrane glycoprotein belonging to the TNF superfamily. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with 4-1BBL strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murine models of cancer, infectious disease and autoimmune disease. Recombinant human 4-1BB ligand, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Species Human
Synonyms Tumor necrosis factor ligand superfamily member 9, TNFSF9, 4-1BBL, CD137L, 4-1BB ligand, 4 1BB L, 4 1BB ligand, 4 1BBL, Cd137l, Cd157l, homolog of mouse 4 1BB L, homolog of mouse 4 1BBL, ILA ligand (TNF related), Ly63l, receptor 4 1BB ligand, Tumor necrosis factor (ligand) superfamily member 9.
Host E.coli
Molecular Weight 53.9 kDa (479 aa), confirmed by MALDI-TOF.
Form Liquid, in 20mM Tris-HCl (pH8.0) buffer containing 10% glycerol
Concentration 1 mg/ml (determined by Bradford assay)
Purity > 95% by SDS-PAGE
Applications SDS-PAGE
NCBI NP_003802
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Intended Use For Research Use Only
References Lee SW., et al. (2008). Nat Immunol. 9(8):917-26
Sharma RK., et al. (2009). Cancer Res. 69(10):4319-26

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