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Anti-Adeno-associated virus (AAV), VP1/VP2/VP3




 

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Product Code: 03-65158


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Product Details
 
Product Code:03-65158
Product:Anti-Adeno-associated virus (AAV), VP1/VP2/VP3
Description:Mouse Monoclonal Antibody to Adeno-associated virus (AAV), VP1/VP2/VP3. Useful for immunolocalization studies of capsid formation in combination with monoclonal antibody A20 (03-61055/65155) and rabbit polyclonal antibody to AAV capsid proteins (03-61084). Reacts with free VP1, VP2 and VP3 and at a very reduced degree with assembled capsids. Recognizes all AAV-serogroups 1-6 (4 reacts weaker).
Category:Mouse monoclonal
Clone:B1
Ig Subtype:IgG1
Background: Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Synonyms:AAV2
Immunogen:Adeno-associated virus capsid proteins and virus particles
Form:Hybridoma culture supernatant
Reactivity:AAV-2, in human & monkey, recognizes AAV serogroups 1-6, (AAV-4 only weak cross reaction)
Specificity:B1 reacts with free VP1, VP2 & VP3 of adeno-associated virus and trace amounts of assembled capsids. VP1 and VP2 distributed in the nucleus and the cytoplasm. Epitope mapping experiments (Wobus et al.) identified aa726 to aa733 (C-terminus, common to all 3VP proteins) as the specific binding region. The antibody is also useful for characterization of different stages of infection.
Applications:Immunofluorescence, Immunohistochemistry, Immunoprecipitation (mainly free VP proteins), Immunoblotting, Affinity Chromatography
Working Dilution:Ready-to-use for immunohistochemical applications
Storage:2-8C
References:
  • Wistuba A, et al. (1995), J. Virol, 69: 5311-5319
  • Wistuba A, et al. (1997), J. Virol, 71: 1341-1352
  • Wobus,CE. et al. (2000) J. Virol 74 (19): 9281-9292
  • Sato Y et al. (1999) Jpn J Infect Dis 52
  • Zhang H-G et al. (2002) J virology 76: 12023-12031
  • Yan Z et al. (2002) J Virology 76: 2043-2055
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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