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Anti-CD233/(Band 3) extracellular domain-PE




 

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Product Code: 08-9439-4


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Product Details
 
Product Code: 08-9439-4
Product Name: Anti-CD233/(Band 3) extracellular domain-PE
Description: Mouse monoclonal antibody to human CD233/(Band3) extracellular domain PE conjugate. CD233 (also known as erythrocyte band 3, EPB3, anion exchange protein 1, AE1, solute carrier family 4, SLC4A1) is an integral membrane protein in human erythrocytes, present at approximately 106 copies per human erythrocyte. It comprises two domains that are structurally and functionally distinct. The cytoplasmic N-terminal 40kDa domain has binding sites for erythrocyte cytoskeletal proteins, namely ankyrin and protein 4.2, which help to maintain the mechanical properties and integrity of the erythrocyte. This domain also binds a number of other erythrocyte peripheral proteins. The 55kDa glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments which function as a chloride/bicarbonate anion exchanger involved in carbon dioxide transport. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. CD233 associates with the erythrocyte membrane protein glycophorin A (GPA) which promotes the correct folding and translocation during biosynthesis of CD23. Many CD233 mutations are known in man and these mutations can lead to two types of disease; destabilization of the erythrocyte membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other CD233 mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. The CD233 gene is located on chromosome 17q21-q2.
Category: Mouse monoclonal
Synonyms: CD233, erythrocyte band 3, EPB3, anion exchange protein 1, AE1, solute carrier family 4, SLC4A1
Clone: BRIC 6
Ig Subtype: Mouse IgG3, kappa light chain
Immunogen: CD233 was made in response to intact human erythrocytes
Form: PE-conjugate, in PBS buffer, pH 7.2 containing 0.1% sodium azide, 1% BSA
Antigen Recognized in Species: Human
Applications: Immunofluorescence, Flow Cytometry
Storage: 2-8C, do not freeze
References: Bruce L.J. and Tanner M.J.A. (Review) PROW 2:9-17 (2001).
Smythe J.S., Spring F.A., Gardner B., Parsons S.F., Judson P.A. and Anstee D.J. Blood 85:2929-2936 (1995).
Steck T.L. J Supramolec Struct 8:311 (1978).
Jennings M.L., Adams-Lackey M., Denney G.H. J Biol Chem 259: 4652 (1984).
Bruce L.J., Ring S.M., Anstee D.J., Reid M.E., Wilkinson S., Tanner M.J.A. Blood 85:541 (1995).
Groves J.D., Ring S.M., Schofield A.E., Tanner M.J.A. FEBS Lett 330: 196 (1983).
Toye A.M. et al (2004) J. Cell Science 117, 1399-1410.
Beckmann R. et al (1998) Blood 92, 4428-4438.
Beckmann R. et al (2001) Blood 97, 2496-2505.
Bruce L. J. et al (2003) Blood 101, 4180-4188
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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