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Anti-CD59-Affinity purified




 

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Product Code: 08-9409-2


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50 µg

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Product Details
 
Product Code:08-9409-2
Product Name:Anti-CD59-Affinity purified
Description:Mouse monoclonal antibody to human CD59 Affinity purified. CD59 (also known as HRF20, MIRL, P18, H19, MAC-inhibitor) is a cell surface glycoprotein of apparent molecular weight 18-20 kDa which contains N- glycans. It is attached to the cell surface by a glycosylphosphatidylinositol tail. The full amino acid sequence derived from cDNA is known. CD59 has been mapped to chromosome 11p14-. It is a complement regulatory protein. It inhibits the terminal stage of the formation of membrane attack complexes by homologous complement activation. CD59 is broadly distributed among haemopoietic and non - haemopoietic cells such as B cells, T cells, monocytes, epithelium, platelets, polymorphonuclear neutrophils and endothelium. Daudi and U937 cells are unreactive. There are approximately 20000-40000 CD59 molecules per erythrocyte. There is reduced expression of CD59 on cells of individuals with paroxysmal nocturnal haemoglobinuria (PNH).
Category:Mouse monoclonal
Synonyms:CD59, HRF20, MIRL, P18, H19, MAC-inhibitor
Clone:BRIC 229
Ig Subtype:Mouse IgG2b kappa light chain
Immunogen:BRIC 229 was made in response to human erythrocytes. The antigen on erythrocytes is sensitive to treatment with Pronase or 6% aminoethylisothiouronium bromide.
Form:Affinity purified, in 0.1 M glycine buffer, 1 M Tris buffer, pH 7.4, sterile filtered
Antigen Recognized in Species:Human
Applications:Immunoblotting, Neutralization
Working Dilution:ELISA, Immunoblotting. It has a functional binding affinity for erythrocytes of 2.8x10^8 M-1
Storage:2-8C for immediate use, or at -20C (aliquot)
References:1. Ojcius et al (1990) Immunology Today 11, 47-49 (Review).
2. Hadam M.R. (1989) in Leucocyte Typing IV; White Cell Differentiation Antigens Ed. W. Knapp et al Oxford University Press pp 720-722.
3. Fletcher A et al. (1992) Immunology, 75: 507-512.
4. van den Berg CW et al.( 1994) J. Immunol., 4095-4101.
5. Zaltzman et al., (1995) Biochem. J., 307: 651-656.
6. Klickstein et al., (1993) Proceedings of the fifth workshop and conference on white cell differentiation antigens, Boston , vol. 2 p1476-1477.
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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