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Anti-p62 Protein, C-Terminal Specific




 
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Product Code: 03-GP62-C


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Product Details
 
Product Code:03-GP62-C
Product:Anti-p62 Protein, C-Terminal Specific
Background:This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Synonyms:SQSTM1, Sequestosome, Ubiquitin-binding protein, p60, p62, A170, OSIL, PDB3, ZIP3, p62B
Category:Guinea pig Polyclonal
Immunogen:C-terminal domain (20 amino acids: C-NYD IGA ALD TIQ YSK HPP PL) of human p62 protein, coupled with KLH. This peptide sequence is identical in human, monkey, bovine, mouse, and rat
Form:Stabilized Serum
Antigen Recognized in Species:Human, Rat, Mouse
Specificity:Human 62 kD (p62) protein, present in intracytoplasmic inclusions (e.g. hyaline bodies) of hepatocellular carcinoma. P62 protein has been found in many tissues and cells, including lymphoid cells, serving probably a common cellular signal transduction mechanism. The antiserum stains also neurofibrillary tangles in the brain of patients suffering from Alzheimer's disease. Note: The p62 antigen might be susceptible to proteolytic degradation. We recommend to use protease inhibitors during sample preparation.
Application:Immunohistochemistry on frozen and paraffin sections (enhanced after microwave treatment), Cytological material, Immunoblotting
Working Dilution:1:100 for immunohistochemistry; 1:1,000 for immunoblotting (ECL method)
Storage:2-8C
References:
  • Stumptner, C. et al. (1999) Am. J. Pathol. 154: 1701-1710
  • Janig, E. et al. (2005) Eur J Cell Biol. 84: 329-339
  • Kuusisto, E. et al. (2007) Neuropathology & Applied Neurobiology, pp 1-12
  • Aishima S et al. (2010) Am J Clin Pathol 134: 457-465
  • Itakura E et al. (2011) J Cell Bio 192: 17-27
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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