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ENSA, 1-121aa, Human, His tag, E.coli

ENSA, 1-121aa, Human, His tag, E.coli


 

Our Price: $159.00

Product Code: 01-1765


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20 µg
100 µg [Add $180.00]
0.5 mg [Add $590.00]

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Product Details
 
Product Code:01-1765
Product:ENSA, 1-121aa, Human, His tag, E.coli
Description:ENSA, also known as alpha endosulfine, belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein is expressed in a wide range of tissues including muscle, brain, and endocrine tissues. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. Recombinant ENSA protein was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms:ARPP-19e, Alpha endosulfine isoform 3 Alpha endosulfine, ARPP 19e, Endosulfine alpha.
NCBI Number:NP_004427
Antigen Species:Human
Applications:SDS-PAGE
Form:Liquid. In 20mM Tris buffer(pH 8.0) containing 10% glycerol, 1mM DTT.
Concentration:1 mg/ml (determined by BCA)
Purity:> 90% by SDS-PAGE
Molecular Weight:15.5 kDa (141aa), confirmed by MALDI-TOF.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV E
Gene Category:Neurodisease
Storage:Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References:
  • Heron L., et al. (1998) Proc Natl Acad Sci U S A. 95(14):8387-91.
  • Kim SH., et al. (2001) J Neural Transm Suppl. 61:1-9.
This product is sold for laboratory research use or further manufacturing only and should not be used for human therapeutic or diagnostic applications. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process.

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