Acy1, 1-408aa, Mouse

Category: Proteins
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01-P3131
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Product Name Acy1, 1-408aa, Mouse
Description Acy1 also known as Aminoacylase1. The protein is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. Recombinant mouse Acy1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Synonyms Aminoacylase 1, ACY-1, Acy1, ACY1_HUMAN, ACY1D, ACYLASE, Acylase I, Aminoacylase-1, EC 3.5.1.14, epididymis secretory protein Li 5, HEL-S-5, N acyl L amino acid amidohydrolase, N-acyl-L-amino-acid amidohydrolase, OTTHUMP00000212459, OTTHUMP00000212462, OTTHUMP00000212463, OTTHUMP00000212464, OTTHUMP00000212465
Host E.coli
Molecular Weight 16.7kDa (150aa) confirmed by MALDI-TOF
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSEFMTTKD PESEHPSVTL FRQYLRICTV QPNPDYGGAI TFLEERARQL GLSCQKIEVV PGFVITVLTW
PGTNPSLPSI LLNSHTDVVP VFKEHWHHDP FEAFKDSEGY IYARGSQDMK SVSIQYLEAV RRLKSEGHRF PRTIHMTFVP DEEVGGHKGM
ELFVKRPEFQ ALRAGFALDE GLANPTDAFT VFYSERSPWW VRVTSTGKPG HASRFIEDTA AEKLHKVISS ILAFREKERQ RLQANPHLKE
GAVTSVNLTK LEGGVAYNVV PATMSASFDF RVAPDVDMKA FEKQLQRWCQ EAGEGVTFEF AQKFTEPRMT PTDDSDPWWA AFSGACKAMN
LTLEPEIFPA ATDSRYIRAV GIPALGFSPM NRTPVLLHDH NERLHEDIFL RGVDIYTGLL SALASVPTLP GES
Tag His-tag
Reactivity Mouse
Applications SDS-PAGE
Form Liquid, in Phosphate Buffer Saline (pH7.4) containing 20% glycerol, 1mM DTT
Concentration 1mg/ml (determined by Absorbance at 280nm)
Purity > 90% by SDS-PAGE
Storage Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
References Miller YE, Drabkin H, et al. (1991) Genomics 8 (1): 149-154.
Voss R, et al. (1982) Ann Hum Genet 44 (Pt 1): 1-9.
Supplier ARP

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