| Product Name | AGR 2, 21-175aa, Human, Recombinant |
|---|---|
| Description | AGR2(Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein(XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor. Recombinant human AGR2, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | AG2, GOB-4, HAG-2, XAG-2, Anterior gradient 2 homolog, AGR 2, Anterior gradient 2 homolog, AGR2, anterior gradient homolog 2 (Xenopus laevis), PDIA17, protein disulfide isomerase family A member 17, Anterior Gradient Protein 2 Homolog |
| Host | E.coli |
| Molecular Weight | 25.1 kDa (231 aa) |
| Amino Acid Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRDT TVKPGAKKDT KDSRPKLPQT LSRGWGDQLI WTQTYEEALY KSKTSNKPLM IIHHLDECPH SQALKKVFAE NKEIQKLAEQ FVLLNLVYET TDKHLSPDGQ YVPRIMFVDP SLTVRADITG RYSNRLYAYE PADTALLLDN MKKALKLLKT EL |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in phosphate-buffered saline (pH 7.4) containing 1 mM DTT |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 95% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| References |
F.R. Fritzsche. et al., (2007). Histol Histopathol. 22: 703-708 Fletcher GC. et al., (2003) Br J Cancer 88(4): 579-85 Liu D. et al., (2005) Cancer Res. 65 : 3796-805 |
| Supplier | ARP |
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