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|Product Name||AK2, 1-239aa, Human, Recombinant|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MAPSVPAAEP EYPKGIRAVL LGPPGAGKGT QAPRLAENFC VCHLATGDML RAMVASGSEL GKKLKATMDA GKLVSDEMVV ELIEKNLETP LCKNGFLLDG FPRTVRQAEM LDDLMEKRKE KLDSVIEFSI PDSLLIRRIT GRLIHPKSGR SYHEEFNPPK EPMKDDITGE PLIRRSDDNE KALKIRLQAY HTQTTPLIEY YRKRGIHSAI DASQTPDVVF ASILAAFSKA TCKDLVMFI|
|Background||Adenylate kinase (AK; adenosine triphosphate-adenosine monophosphate [ATP-AMP] phospho-transferase, EC 188.8.131.52) is a ubiquitous monomeric enzyme involved energy metabolism of prokaryotic and eukaryotic cells. Three isozymes (AK1, AK2 and AK3) are characterized in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Recombinant human AK2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Form||Liquid, in Phosphate Buffered Saline pH7.4|
|Intended Use||For Research Use Only|
|Molecular Weight||32 kDa (245 aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_001616.1|
|Purity||> 95% by SDS-PAGE|
|References||Kohler C., et al. (1999).FEBS Lett. 447(1):10-2
Lee Y., et al. (1998).J Biol Chem. 123(1):47-54
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||ADK2, AK2, Adenylate kinase 2, Adenylate kinase isoenzyme 2, ATP AMP transphosphorylase, EC 184.108.40.206|
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