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|Product Name||Aldose reductase, 1-316aa, Human, Recombinant|
|Amino Acid Sequence||MASRLLLNNG AKMPILGLGT WKSPPGQVTE AVKVAIDVGY RHIDCAHVYQ NENEVGVAIQ EKLREQVVKR EELFIVSKLW CTYHEKGLVK GACQKTLSDL KLDYLDLYLI HWPTGFKPGK EFFPLDESGN VVPSDTNILD TWAAMEELVD EGLVKAIGIS NFNHLQVEMI LNKPGLKYKP AVNQIECHPY LTQEKLIQYC QSKGIVVTAY SPLGSPDRPW AKPEDPSLLE DPRIKAIAAK HNKTTAQVLI RFPMQRNLVV IPKSVTPERI AENFKVFDFE LSSQDMTTLL SYNRNWRVCA LLSCTSHKDY PFHEEF|
|Background||Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) superfamily and catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. This protein is implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Recombinant Aldose reductase (AKR1B) protein was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||1 mg/ml (determined by Bradford assay)|
|Endotoxin Level||< 1.0 EU per 1 microgram of protein (determined by LAL method)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH8.0) , 2mMDTT, 20% Glycerol|
|Intended Use||For Research Use Only|
|Molecular Weight||29.3 kDa (259 aa), confirmed by MALDI-TOF.|
|NCBI Accession #||NP_001619|
|Purity||> 95% by SDS-PAGE|
|References||Ruiz FX., et al: (2009) Chem Biol Interact.178(1-3)
Donaqhue KC., et al: Diabet Med. 22(10):1315-20
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||AKR1B1, ADR, ALDR1, ALR2, AR, Aldo-keto reductase family1 member B1, Aldose reductase, Aldo-keto reductase family1, member B1 AKR1B 1, Aldehyde reductase, aldehyde reductase 1, aldo-keto reductase family 1, member B1 aldr 1, aldr-1, Lii5-2 CTCL tumor antigen, low Km aldose reductase.|
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