| Product Name | Alpha-2-macroglobulin |
|---|---|
| Description | Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases. |
| Synonyms | A2M, A2MD, CPAMD5, FWP007, S863-7 |
| Molecular Weight | 725000 |
| Form | Purified protein, in 30 mM Na Phosphate, pH 7.0 , with glycine as a stabilize and 0.1% sodium azide. |
| Purity | Greater than 95% determined by SDS-PAGE. Cellulose acetate electrophoresis shows the major product to have alpha-2 mobility. Protein determination by the method of Lowry and Polyacrylamide gradient gel electrophoresis shows one band only corresponding the molecular weight of Alpha-2-macroglobulin. |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| Notes | Because no test method can offer complete assurance that products derived from human source will not transmit infectious agents, it is recommended that this product be handled with the same precautions used for patient specimens. |
| Supplier | ARP |
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