Alpha A Crystallin Antibody: ATTO 633

Category: Antibodies
Catalog
SMC-142B-A633
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Product Name Alpha A Crystallin Antibody: ATTO 633
Description The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Mouse Anti-Human Alpha A Crystallin Monoclonal IgG1
Synonyms Heat shock protein beta4 Antibody, Acry 1 Antibody, CRYA1 Antibody, CRYAA Antibody, HSPB4 Antibody
Host Mouse
Clone 1H3.B8
Immunogen Native Alpha Crystallin
Isotype IgG1
Specificity Detects ~20kDa. Does not cross-react with αB-crystallin, βL-crystallin, ΒH- crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
Reactivity Bovine, Human, Mouse, Rat
Applications ELISA, ICC, IF, WB
Form Purified, in PBS pH7.2, 50% glycerol, 0.09% sodium azide
Gene Id NP_000385.1. 1409
Uniprot P02489
Supplier Stressmarq Biosciences

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