Alpha Actinin

Category: Proteins
Catalog
03-62002
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Product Name Alpha Actinin
Description Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. Alpha Actinin purified from chicken gizzard
Synonyms F-actin cross-linking protein, actinin 1 smooth muscle, alpha-actinin cytoskeletal isoform, alpha-actinin-1, non-muscle alpha-actinin-1
Molecular Weight 95000
Applications ELISA
Form Lyophilized, salt balanced.
Purity > 95%, SDS-PAGE
Storage 4C (lyophilized); at -20C (solution, aliquot)
References Duhaiman, A.S. and Bamburg, J.R. (1984) Biochem. 23: 1600

Feramisco, J.R. and Burridge, K. (1980) J. Biol. Chem. 255: 1194
Supplier ARP

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