| Product Name | Alpha Synuclein Antibody: Biotin |
|---|---|
| Description | Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). . Mouse Anti-Human Alpha Synuclein Monoclonal IgG1 |
| Synonyms | Alpha Synuclein Antibody, Non-A beta component of AD amyloid Antibody, Non-A4 component of amyloid precursor Antibody, NACP Antibody, SNCA Antibody, PARK1 Antibody, PARK 1 Antibody, alphaSYN Antibody, PARK 4 antibody, PARK4 antibody, Parkinson disease fam |
| Host | Mouse |
| Clone | 3C11 |
| Immunogen | Human alpha synuclein monomer |
| Isotype | IgG1 |
| Specificity | Binds within the 81-130 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~30 kDa is a dimer. |
| Reactivity | Human, Mouse, Rat |
| Applications | DB, ELISA, ICC, IF, WB |
| Form | Purified, in PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide |
| Gene Id | NP_000336.1. 6622 |
| Uniprot | P37840 |
| Supplier | Stressmarq Biosciences |
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