| Product Name | Anti-Adeno-Associated Virus (AAV-8), intact particles |
|---|---|
| Description | Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Mouse Monoclonal Antibody to Adeno-Associated Virus (AAV-8), intact particles. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. |
| Synonyms | AAV8 |
| Clone | ADK8 |
| Immunogen | Recombinantly produced adeno-associated virus type 8 (AAV-8) vector, carrying GFP |
| Isotype | IgG2a,Kappa |
| Specificity | Recognizes a conformational epitope of assembled capsids. Predicted binding site: residues 586-LQQQNT-591 (cf. Gurda et al.). The antibody cannot be used for immunoblotting using denaturing conditions. |
| Reactivity | Primate |
| Applications | ELISA, IF, IHC, IP |
| Form | Culture supernatant (concentrate and purified IgG available on request) |
| Storage | 2-8C |
| References | Sonntag F, KÌÄå¦ther K, Schmidt K, Weghofer M, Raupp C, Nieto K, Kuck A, Gerlach B, BÌÄå¦ttcher B, MÌÄå_ller OJ, Lux K, HÌÄå¦rer M, Kleinschmidt JA: The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes. J Virology 85, 12686-12697 (2011)Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M: Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. J Virology 86, 7739-7751 (2012)Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R: OneBac:Platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy. Hum Gene Ther 25, 212-222 (2014); doi: 10.1089/hum.2013.184 |
| Supplier | ARP |
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