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|Product Name||Anti-Adeno-Associated Virus (AAV), Rep Protein|
|Description||Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Mouse Monoclonal Antibody to Adeno-Associated Virus (AAV), Rep Protein. Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in human AAV-2-infected cells. Cross-reactivity with AAV serotypes 1, 3, 4, 5, and 6. A weak cross-reactivity is seen in some human cell lines.|
|Background||Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models|
|Immunogen||Rec.AAV-2 Rep 78 protein, N-terminally truncated by 171 aa|
|Specificity||Mab 259.5 reacts with Rep proteins (Rep78, Rep68, Rep52 and Rep40) of human AAV-2-infected cells|
|Form||Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide|
|Storage||2-8C for immediate use, or at -20C (aliquot)|
|References||Wobus,CE. et al. (2000) J. Virol 74 (19): 9281-9292Wistuba, A. et al. (1995) J. Virol. 69: 5311-5319|
|Intended Use||For Research Use Only|
|FDA Status||For Research Use Only|
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