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|Product Name||Anti-Adeno-associated virus type 5 (AAV-5), intact particles|
|Description||Mouse Monoclonal Antibody to Adeno-Associated Virus, serotype 5 (AAV-5), intact particles. Specifically detects intact virus particles, both empty and full capsids. ADK5a recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting.|
|Background||Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models|
|Immunogen||Adeno-associated virus type 5 (AAV-5) capsid proteins and virus particles|
|Specificity||For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK5a specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins.|
|Reactivity||AAV-5 found in human & monkey|
|Applications||ELISA, IF, IHC, IP|
|Form||Affinity purified, 0.09 % sodium azide, 0.5% BSA in PBS buffer, pH 7.4|
|Storage||2-8C for immediate use, or at -20C (aliquot)|
|References||Kuck, D et al. (2007) Virol Methods 140: 17-24|
|Intended Use||Limited Use Label License: Research Use Only
Product is exclusively licensed to PROGEN Biotechnik GmbH. The use of these products for the development, manufacturing and sale of secondary products/derivatives which are based on the purchased products and/or which include the purchased product require a royalty based sub-license agreement.
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