Anti-Adeno-associated virus type 5 (AAV-5), intact particles, Supernatant Concentrate

Category: Anti-AAV Products
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03-652148
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Product Name Anti-Adeno-associated virus type 5 (AAV-5), intact particles, Supernatant Concentrate
Description Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models. Mouse Monoclonal Antibody to Adeno-Associated Virus, serotype 5 (AAV-5), intact particles. Specifically detects intact virus particles, both empty and full capsids. ADK5a recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting.
Synonyms AAV5
Clone ADK5a
Immunogen Adeno-associated virus type 5 (AAV-5) capsid proteins and virus particles
Isotype IgG2a,Kappa
Specificity For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK5a specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids, not present in denatured capsid proteins and native but unassembled capsid proteins.
Applications ELISA, IF, IHC, IP
Form Hybridoma cell culture supernatant concentrate, contains 0.09% sodium azide
Storage 2-8C for immediate use, or at -20C (aliquot)
References Tseng, Y.-S. et al. Adeno-Associated Virus Serotype 1 (AAV1)-and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity. J. Virol. 89, 1794‰â‰ÛÏ1808 (2015).



Mietzsch, M. et al. OneBac: Platform for Scalable and High-Titer Production of Adeno-Associated Virus Serotype 1‰â‰ÛÏ12 Vectors for Gene Therapy. Hum. Gene Ther. 25, 212‰â‰ÛÏ222 (2014).



Kuck, D et al. (2007) Virol Methods 140: 17-24
Supplier ARP

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