Anti-Adeno-Associated Virus Type 9 (AAV9), intact particles
| Product Name | Anti-Adeno-Associated Virus Type 9 (AAV9), intact particles |
|---|---|
| Description |
- . Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models.Mouse Monoclonal Antibody to Anti-Adeno-Associated Virus Type 9 (AAV9), intact particles (formerly SKU 03-610162). |
| Synonyms | AAV9 |
| Host | Mouse |
| Clone | ADK9 |
| Immunogen | AAV9 capsids |
| Isotype | IgA,k |
| Specificity |
For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK9 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. The antibody cannot be used for immunoblotting. The antibody is also useful for neutralizing experiments. This antibody cannot be used for immunoblotting. |
| Reactivity | Human |
| Applications | ELISA, DOT, IF, IHC |
| Form | liquid; PBS with 0.09% sodium azide and 0.5% BSA |
| Storage | Short term at 2-8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles |
| References |
1. Sonntag F, KÌÄå¦ther K, Schmidt K, Weghofer M, Raupp C, Nieto K, Kuck A, Gerlach B, BÌÄå¦ttcher B, MÌÄå_ller OJ, Lux K, HÌÄå¦rer M,Kleinschmidt JA: The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes. J Virology85, 12686-12697 (2011) 2. Mietzsch M, Grasse S, Zurawski C, Weger S, Bennett A, Agbandje-McKenna M, Muzyczka N, Zolotukhin S, Heilbronn R: OneBac: Platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy. Hum Gene Ther 25, 212-222 (2014); doi: 10.1089/hum.2013.184 |
| Supplier | ARP |
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