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|Product Name||Anti-ADK (clone AT4F8)|
|Description||Adenosine kinase (ADK) is the key regulator of adenosine metabolism. Because of the manifold receptor-dependent actions of adenosine, tight regulation of adenosine levels is crucial. The intracellular and extracellular pools of adenosine are in dynamic exchange by equilibrative and concentrative nucleoside transporters, so extracellular concentrations of adenosine are regulated by interplay of theses transporters with intracellular and extracellular enzymes of adenosine metabolism. Thus, the extracellular concentration of adenosine is enhanced by inhibition of equilibrative nucleoside transporters such as S-(4-nitrobenzyl)-6-thioinosine and cannabidiol and, stimulation of extracellular ATP breakdown and inhibition of intracellular adenosine removal.|
|Applications||Dot blot, ELISA, WB|
|Clone||AT4F8. Anti-human ADK mAb, clone AT4F8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ADK protein.|
|Form||Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide|
|Immunogen||Recombinant human ADK (22-362aa) purified from E. coli|
|Interest Fields||Signal Transduction|
|References||Mathews II , et al. (1998). Biochemistry 10;37(45):15607-20. Lindberg B, Klenow H, Hansen K (1967). J. Biol. Chem. 242 (3): 350-6. CAPUTTO R (1951). J. Biol. Chem. 189 (2): 801-14.|
|Storage||Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.|
|Synonyms||ADK, AK, adenosine kinase, adenosine 5'-phosphotransferase,|
|Working Dilutions||Optimal dilution should be performed by user.|
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