Anti-ADK (clone AT4F8)

Catalog
01-A0206
$0.00
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Antibodies, Monoclonal Antibodies
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Product Name Anti-ADK (clone AT4F8)
Description Adenosine kinase (ADK) is the key regulator of adenosine metabolism. Because of the manifold receptor-dependent actions of adenosine, tight regulation of adenosine levels is crucial. The intracellular and extracellular pools of adenosine are in dynamic exchange by equilibrative and concentrative nucleoside transporters, so extracellular concentrations of adenosine are regulated by interplay of theses transporters with intracellular and extracellular enzymes of adenosine metabolism. Thus, the extracellular concentration of adenosine is enhanced by inhibition of equilibrative nucleoside transporters such as S-(4-nitrobenzyl)-6-thioinosine and cannabidiol and, stimulation of extracellular ATP breakdown and inhibition of intracellular adenosine removal.
Reactivity Human
Applications Dot blot, ELISA, WB
Clone AT4F8. Anti-human ADK mAb, clone AT4F8, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ADK protein.
Concentration 0.1 mg/ml
Form Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Species Mouse
Host Mouse
Isotype IgG1, K
Immunogen Recombinant human ADK (22-362aa) purified from E. coli
Interest Fields Signal Transduction
NCBI Number NP_006712
References Mathews II , et al. (1998). Biochemistry 10;37(45):15607-20. Lindberg B, Klenow H, Hansen K (1967). J. Biol. Chem. 242 (3): 350-6. CAPUTTO R (1951). J. Biol. Chem. 189 (2): 801-14.
Storage Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Synonyms ADK, AK, adenosine kinase, adenosine 5'-phosphotransferase,
Working Dilutions Optimal dilution should be performed by user.

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