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|Product Name||Anti-APEX2 Polyclonal Antibody|
|Description||Rabbit IgG polyclonal antibody for DNA-(apurinic or apyrimidinic site) lyase 2(APEX2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.|
|Background||APEX2, also called apurinic/apyrimidinic endonuclease like-2, is a member of the apurinic/apyrimidinic(AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected APEX2 expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue. The APEX2 gene contains 6 exons. The APEX2 gene is mapped to chromosome Xp11.21. APEX2 participates in both nuclear and mitochondrial base excision repair(BER). APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1. APEX2 plays a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human APEX2(504-518aa DPSSRCNFFLWSRPS), identical to the related rat and mouse sequences.|
|Synonyms||AP endonuclease 2 antibody, AP endonuclease XTH2 antibody, APE 2 antibody, APE2 antibody, APEX 2 antibody, APEX L2 antibody, APEX nuclease(apurinic/apyrimidinic endonuclease) 2 antibody, APEX nuclease 2 antibody, APEX nuclease like 2 antibody, APEX nuclease-like 2 antibody, APEX2 antibody, APEX2_HUMAN antibody, APEXL 2 antibody, APEXL2 antibody, Apurinic apyrimidinic endonuclease 2 antibody, Apurinic-apyrimidinic endonuclease 2 antibody, Apurinic/apyrimidinic endonuclease 2 antibody, Apurinic/apyrimidinic endonuclease like 2 antibody, C430040P13Rik antibody, DNA(apurinic or apyrimidinic site) lyase 2 antibody, DNA apurinic or apyrimidinic site lyase 2 antibody, DNA-(apurinic or apyrimidinic site) lyase 2 antibody, EC 22.214.171.124 antibody, OTTHUMP00000023390 antibody, OTTHUMP00000061908 antibody, XTH 2 antibody, XTH2 antibody|
|Specificity||No cross reactivity with other proteins.|
|Reactivity||Predicted to work with: mouse, Rat, Reacts with: human|
|Form||Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
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