Anti-Arginase 1 (Hepatocellular Carcinoma Marker), Monoclonal Antibody
| Product Name | Anti-Arginase 1 (Hepatocellular Carcinoma Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma. |
| Synonyms | Arginase 1, ARG1, liver-type arginase, type I arginase |
| Host | Mouse |
| Clone | ARG1/1125 |
| Immunogen | Recombinant fragment (87 Amino acid residues around aa 1-150) of human ARG1 protein |
| Isotype | IgG3, kappa |
| Reactivity | Human |
| Applications | FC, IF, IHC, WB |
| Form | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Gene Id | 383 |
| Uniprot | P05089 |
| Storage | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Diez, A., et al. 1994. Immunological identity of the two different molecular mass constitutive subunits of liver arginase. Biol. Chem. Hoppe Seyler 375: 537-541 |
| Supplier | ARP |
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