Anti-Carcinoembryonic Antigen (CEA) / CD66, Monoclonal Antibody

Category: Antibodies
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24-1048-MSM2
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Product Name Anti-Carcinoembryonic Antigen (CEA) / CD66, Monoclonal Antibody
Description This monoclonal antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. CEA is synthesized during development in the fetal gut and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. This monoclonal antibody reacts with nonspecific cross-reacting antigen (NCA) and shows a cross-reaction with human polymorphonuclear leucocytes. It shows no reaction with a variety of normal tissues and is suitable for staining of formalin/paraffin tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Anti-CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, pancreas, gallbadder, urachus, salivary gland, ovary, and endocervix._
Synonyms Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66, Biliary Glycoprotein (BGP-1)
Host Mouse
Clone C66/195
Immunogen Recombinant full-length human CEA protein
Isotype IgG1, kappa
Reactivity Human, Primate
Applications FC, IF, IHC
Form 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Gene Id 1048 & 634
Uniprot P06731
Storage Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
References Muraro R, et. al. Cancer Research, 1985, 45:5769-80.
Siler K, et. al. Biotechnology Therapeutics, 1993, 4(3-4):163-81.
Robbins PF, et. al. International Journal of Cancer, 1993, 53(6):892-7
Supplier ARP

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