Anti-CCR3 Polyclonal Antibody

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Product Name Anti-CCR3 Polyclonal Antibody
Description C-C chemokine receptor type 3, also called CCR3 or CKR3 is a protein that in humans is encoded by the CCR3 gene. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. This receptor binds and responds to a variety of chemokines, including eotaxin(CCL11), eotaxin-3(CCL26), MCP-3(CCL7), MCP-4(CCL13), and RANTES(CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. Alternatively spliced transcript variants have been described. Rabbit IgG polyclonal antibody for C-C chemokine receptor type 3(CCR3) detection. Tested with WB, IHC-P, ICC in Human.
Applications ICC, IHC, WB
Background C-C chemokine receptor type 3, also called CCR3 or CKR3 is a protein that in humans is encoded by the CCR3 gene. The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. This receptor binds and responds to a variety of chemokines, including eotaxin(CCL11), eotaxin-3(CCL26), MCP-3(CCL7), MCP-4(CCL13), and RANTES(CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. Alternatively spliced transcript variants have been described.
Form Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human CCR3(1-20aa MTTSLDTVETFGTTSYYDDV).
Isotype Rabbit IgG
Reactivity Human
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity No cross reactivity with other proteins.
Synonyms B Chemokine Receptor antibody, b-chemokine receptor antibody, C C chemokine receptor type 3 antibody, C C CKR 3 antibody, C-C chemokine receptor type 3 antibody, C-C CKR-3 antibody, CC Chemokine Receptor 3 antibody, CC chemokine receptor type 3 antibody, CC CKR 3 antibody, CC R3 antibody, CC-CKR-3 antibody, CCCKR3 antibody, CCR 3 antibody, CCR-3 antibody, CCR3 antibody, CCR3_HUMAN antibody, CD 193 antibody, CD193 antibody, CD193 antigen antibody, Chemokine(C C motif) receptor 3 antibody, chemokine(C-C motif) receptor 3 antibody, Chemokine(CC) Receptor 1 Like 2 antibody, Chemokine CC Motif Receptor 3 antibody, Chemokine receptor 3 antibody, CK R3 antibody, CKR 3 antibody, CKR3 antibody, CMKB R3 antibody, CMKBR 3 antibody, CMKBR1L2 antibody, CMKBR3 antibody, Eosinophil CC Chemokine Receptor 3 antibody, Eosinophil Eotaxin Receptor antibody, Eotaxin Receptor antibody, Macrophage inflammatory protein 1 alpha receptor like 2 antibody, Macrophage Inflammatory Protein1 Alpha Receptor Like 2 antibody, MGC102841 antibody, MIP1 Alpha RL2 antibody
Uniprot P51677
Host Rabbit

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