| Product Name | Anti-CD20 / MS4A1 (B-Cell Marker), Monoclonal Antibody |
|---|---|
| Description | Recognizes a protein of 30-33kDa, which is identified as CD20. Its epitope is located in the cytoplasmic domain of CD20 and was, therefore, ascribed as CD20cy in the 5th Workshop. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This monoclonal antibody can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin_Ûªs disease, particularly of lymphocyte predominant type. |
| Synonyms | APY, ATOPY, B-lymphocyte antigen CD20, B-lymphocyte cell-surface antigen B1, Bp35, Fc epsilon receptor I beta chain, Fc Fragment of IgE high affinity I receptor for beta polypeptide, FCER1B, High affinity immunoglobulin epsilon receptor subunit beta, IgE Fc receptor subunit beta, IGEL, IGER, IGHER, LEU16, Leukocyte surface antigen Leu-16, Ly44, Membrane spanning 4 domains subfamily A member 2, Membrane-spanning 4-domains subfamily A member 1 (MS4A1) |
| Host | Mouse |
| Clone | L26 + IGEL/773 |
| Immunogen | Human tonsil B cells (L26); Recombinant human MS4A1 protein (IGEL/773) |
| Isotype | IgG's |
| Reactivity | Canine, Human, Porcine, Primate, Rat |
| Applications | FC, IF, IHC |
| Form | Tissue culture supernatant with 0.05% Azide. Contact us if you require it in a different format. |
| Gene Id | 931 |
| Uniprot | P11836 |
| Storage | Store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
| References | Schlossman, S., et al., eds. 1995. Leucocyte Typing V. New York: Oxford University Press |
| Supplier | ARP |
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