Anti-CD244 Polyclonal Antibody

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Product Name Anti-CD244 Polyclonal Antibody
Description CD244(Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Tangye et al.(1999) mapped the 2B4 gene to 1q22. Suzuki et al.(2008) identified a functional single-nucleotide polymorphism(SNP) in the CD244 gene that contributes to rheumatoid arthritis susceptibility. Functional analysis by Boles et al.(1999) demonstrated that engagement of 2B4 with specific antibody activates NK cytolytic activity. Using recombinant human NK cell-activating ligand 2B4 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, Brown et al.(1998) demonstrated that CD48 binds to 2B4. Watzl et al.(2000) showed that antibody-mediated cross-linking of 2B4 leads to its rapid tyrosine phosphorylation, which is necessary for 2B4-mediated killer cell activity. Rabbit IgG polyclonal antibody for Natural killer cell receptor 2B4(CD244) detection. Tested with WB, IHC-P in Human.
Background CD244(Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Tangye et al.(1999) mapped the 2B4 gene to 1q22. Suzuki et al.(2008) identified a functional single-nucleotide polymorphism(SNP) in the CD244 gene that contributes to rheumatoid arthritis susceptibility. Functional analysis by Boles et al.(1999) demonstrated that engagement of 2B4 with specific antibody activates NK cytolytic activity. Using recombinant human NK cell-activating ligand 2B4 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, Brown et al.(1998) demonstrated that CD48 binds to 2B4. Watzl et al.(2000) showed that antibody-mediated cross-linking of 2B4 leads to its rapid tyrosine phosphorylation, which is necessary for 2B4-mediated killer cell activity.
Host Rabbit
Isotype Rabbit IgG
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human CD244(357-370aa RLSRKELENFDVYS).
Synonyms 2B4 antibody, C9.1 antibody, CD244 antibody, CD244 antigen antibody, CD244 molecule natural killer cell receptor 2B4 antibody, CD244 natural killer cell receptor 2B4 antibody, CD244_HUMAN antibody, F730046O15Rik antibody, h2B4 antibody, Ly90 antibody, NAIL antibody, Natural killer cell activation-inducing ligand antibody, Natural killer cell receptor 2B4 antibody, NK cell activation inducing ligand antibody, NK cell activation inducing ligand NAIL antibody, NK cell activation-inducing ligand antibody, NK cell type I receptor protein 2B4 antibody, NKR2B4 antibody, Nmrk antibody, Non-MHC restricted killing associated antibody, OTTHUMP00000027884 antibody, p38 antibody, SLAM family, member 4 antibody, SLAMF4 antibody
Specificity No cross reactivity with other proteins.
Reactivity Human
Applications IHC, WB
Form Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Uniprot Q9BZW8

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