| Product Name | Anti-Collagen Type IV Monoclonal Antibody |
|---|---|
| Description | Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mouse Monoclonal Antibody tohuman placental type IV collagen. |
| Clone | 1042 |
| Immunogen | Human placental type IV collagen |
| Isotype | IgG2b |
| Specificity | Mab 1042 is reactive with human collagen type IV of basement membranes, and shows a homogeneous staining pattern in all tissues. As neoplastic cells of invasive carcinomas often lack a continuous basement membrane, the antibody is useful to distinguish between non-invasive and invasive lesions. Additionally, it can be used for the differentiation of bullous lesions in dermatopathology. No cross-reactivity with other collagens |
| Reactivity | Human |
| Applications | ELISA, IHC, WB |
| Form | Ascites containing 0.1% sodium azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Havenitz, M.G. et al. (1987) Histochemistry 87 : 123-128 |
| Supplier | ARP |
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