| Product Name | Anti-Complement C3b-Beta Antibody (H11) Monoclonal Antibody |
|---|---|
| Description | Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. Mouse Monoclonal antibody to C3b-beta clone H11. Detection of C3b deposits in tissue, on cells, on microorganisms and in immune complexes. It should be used with positive control anti C3b-alpha, (H206, Cat. #: 03-61019) and negative control anti C3a (H13, Cat. #: 03-61018). Activated, deposited C3b bears C3b-alpha and -beta, but no longer C3a. Ubiquitous or nonspecifically absorbed C3 is still C3a positive with H13. Polypeptide reacting: C3b beta-chain. |
| Clone | H11 |
| Immunogen | Human complement component C3 |
| Isotype | IgG1 |
| Specificity | Clone H11 allows demonstration of C3b deposits in tissue, on cells, on microorganisms and in immune complexes. It does not react with C3a or C3d; inhibits hemolytic function of C3. |
| Reactivity | Human |
| Applications | IHC, WB |
| Form | Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide |
| Storage | 2-8C for immediate use, or at -20C (aliquot) |
| References | Burger, R.et al. (1987) Clin Exp. Immunol. 68: 703-711 Sugita, K. et al. (1987) Transplantation 43: 4 570-574 Burger R et al. (1989) Aerztl Lab 35: 265-270 Zillow G et al. (1989) J Immunol Methods 121: 261-268 |
| Supplier | ARP |
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