Anti-Cytokeratin 8 (KRT8), Monoclonal Antibody

Monoclonal Antibodies
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Product Name Anti-Cytokeratin 8 (KRT8), Monoclonal Antibody
Description Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ðring-like, perinuclearð) from ductal (ðperipheral-predominantð) carcinoma of the breast.
Host Mouse
Clone B22.1
Isotype IgG1, kappa
Immunogen Cytoskeletal preparation from HeLa cells
Synonyms CARD2, CK8, CYK8, CYKER, Cytokeratin Endo A, DreK8, EndoA, K2C8, K8, Keratin 8, Krt 2.8, KRT8, Type-II Keratin Kb8
Reactivity Chicken and xenopus laevis. Others not known., Cow and Pig. Does not react with mouse, Human, Rabbit, Rat, Sheep
Applications FC, IF, IHC
Form 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
SwissProt P05787
Entrez ID 3856
Unigene 533782 & 708445
Storage Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
References Guelstein VI et. al. Int J Cancer 42:147-53 (1988)
Intended Use For Research Use Only

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