Anti-Cytokeratin/Keratin K17 Monoclonal Antibody

Category: Antibodies
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03-65136
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Product Name Anti-Cytokeratin/Keratin K17 Monoclonal Antibody
Description This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Mouse Monoclonal Antibody to Cytokeratin/Keratin K17. Polypeptide recognized: Human keratin K17 of Mr 46,000
Synonyms PC, K17, PC2, PCHC1
Clone Ks 17.E3
Immunogen Human keratin K17 of Mr 46,000
Isotype IgG2b
Specificity Ks 17.E3 represents an excellent marker to distinguish myoepithelial cells (positive for K17) from luminal epithelium of various glands (mammary, sweat, salivary, bronchial, tracheal, laryngeal, esophageal) and benign from malignant forms of e.g. mammary gland tumors. In the epidermis suprabasal staining is found only in cornifying regions and in the outer root sheath of hair follicles. Tumors specifically detected: Benign tumors of mammary gland; most malignant forms of mammary tumors are negative for keratin K17.
Reactivity Human, Rat
Applications WB
Form Hybridoma culture supernatant
Storage 2-8C
References Guelstein, V.I. et al. (1988) Int. J. Cancer 42: 147-153Troyanowsky, S.M et al. (1989) J. Cell. Sc. 93: 419-426Smedts, F. et al. (1991) Arch. Dermatol. Res. 283: 300-309De Jong, E. et al. (1991) Arch. Dermatol. Res. 283: 480-482Demirkesen, C. et al. (1995) J Cutan. Pathol 22: 518-535Moll, R. et al. (1995) Differenzierungsmarker bei gynaekologischen Tumoren: Methodische und diagnostische Aspekte. In: Aktuelle Aspekte der Tumorimmunologie in der Gynaekologie. W. Zuckschwerdt Verlag.
Supplier ARP

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