Anti-Desmoplakin 1&2 Monoclonal Antibody

Monoclonal Antibodies
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Product Name Anti-Desmoplakin 1&2 Monoclonal Antibody
Description DP1&2-2.15 shows distinct punctate membrane staining of different epithelia. Tumors specifically detected: Primary and metastatic carcinoma and meningioma. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000).
Background Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
Clone DP1&2-2.15
Isotype IgG1
Immunogen Bovine desmoplakin 1&2
Synonyms DP, DPI, DPII
Specificity Reactivities on cultured cell line: Primary and metastatic carcinoma; meningioma
Reactivity Bovine, Chicken, Human, Mouse, Rat
Applications IHC, WB
Form Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide
Storage 2-8C for immediate use, or at -20C (aliquot)
References Cowin, P., Kapprell, H.P. and Franke, W.W. (1985) J. Cell Biol. 101: 1442-1454Dockhorn-Dworniczak, B. et al. (1987) Differentiation 35: 53-71Franke, W.W. et al. (1983) PNAS USA 80: 543-547Franke, W.W. et al. (1988) In: Endothelial Cell Biology. N. Simionescu et al., eds. Plenum Publishing Corp., New York, pp. 147-165Koch, Pj. Et al. (1990) Eur. J. Cell Biol. 53: 1-12Moll, I. & Moll, R. (1991) Arch. Dermatol. Res. 283: 300-309Moll, R. et al. (1986) Lab. Invest. 54: 4-25Owaribe, K. et al. (1990) Differentiation 45: 207-220Schmelz, M. & Franke, WW (1993) Eur. J. Cell. Biol. 61: 274-289Hatzfeld, M. et al. (2000) J. Cell Biol. 149: 209-222
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