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|Product Name||Anti-Desmoplakin 1&2 Monoclonal Antibody|
|Description||DP1&2-2.15 shows distinct punctate membrane staining of different epithelia. Tumors specifically detected: Primary and metastatic carcinoma and meningioma. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000).|
|Background||Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.|
|Immunogen||Bovine desmoplakin 1&2|
|Synonyms||DP, DPI, DPII|
|Specificity||Reactivities on cultured cell line: Primary and metastatic carcinoma; meningioma|
|Reactivity||Bovine, Chicken, Human, Mouse, Rat|
|Form||Purified (Protein A), in PBS containing 1% BSA and 0.1% sodium-azide|
|Storage||2-8C for immediate use, or at -20C (aliquot)|
|References||Cowin, P., Kapprell, H.P. and Franke, W.W. (1985) J. Cell Biol. 101: 1442-1454Dockhorn-Dworniczak, B. et al. (1987) Differentiation 35: 53-71Franke, W.W. et al. (1983) PNAS USA 80: 543-547Franke, W.W. et al. (1988) In: Endothelial Cell Biology. N. Simionescu et al., eds. Plenum Publishing Corp., New York, pp. 147-165Koch, Pj. Et al. (1990) Eur. J. Cell Biol. 53: 1-12Moll, I. & Moll, R. (1991) Arch. Dermatol. Res. 283: 300-309Moll, R. et al. (1986) Lab. Invest. 54: 4-25Owaribe, K. et al. (1990) Differentiation 45: 207-220Schmelz, M. & Franke, WW (1993) Eur. J. Cell. Biol. 61: 274-289Hatzfeld, M. et al. (2000) J. Cell Biol. 149: 209-222|
|Intended Use||For Research Use Only|
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