Product Name | Anti-Desmoplakin 1&2 Monoclonal Antibody |
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Description | Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. Mouse Monoclonal Antibody to Desmoplakin 1&2. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000) |
Synonyms | DP, DPI, DPII |
Clone | DPI/II 236.23.1 |
Immunogen | C-terminal polypeptide of Recombinant human desmoplakin (starting at amino acid position 1980) |
Isotype | IgG2b |
Specificity | The antibody shows distinct punctate membrane staining of different epithelia. Desmosomes of the myocardium are also positive. Tumors specifically detected: Primary and metastatic carcinoma and meningioma. |
Reactivity | Amphibian, Bovine, Human, Mouse |
Applications | IF, IHC, WB |
Form | Hybridoma culture supernatant |
Storage | 2-8C |
References | Cowin, P.et al. (1985). J. Cell Biol. 101: 1442-1454Dockhorn-Dworniczak, B.et al. (1987). Differentiation 35: 53-71Franke, W.W.et al. (1983). Proc. Natl. Acad. Sci., USA, 80: 543-547Moll, R.et al. (1986). Lab. Invest. 54: 4-25Koch, PJ. Et al. (1990) Eur. J. Cell Biol. 53: 1-12Moll, R. et al. (1991) Arch Dermatol Res. 283: 300-309Owaribe, K. et al. (1990) Differentiation 45: 207-220Owaribe, K. et al. (1992) Exp. Cell. Rev 1992: 622-630Schmelz, M. & Franke, WW (1993) Eur. J. Cell Biol. 61: 274-289 |
Supplier | ARP |
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