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|Product Name||Anti-Desmoplakin 1&2 Monoclonal Antibody|
|Description||Mouse Monoclonal Antibody to Desmoplakin 1&2. Polypeptides reacting: Desmoplakin 1 and 2 (Mr 250 000 and 215 000)|
|Background||Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.|
|Immunogen||C-terminal polypeptide of Recombinant human desmoplakin (starting at amino acid position 1980)|
|Synonyms||DP, DPI, DPII|
|Specificity||The antibody shows distinct punctate membrane staining of different epithelia. Desmosomes of the myocardium are also positive. Tumors specifically detected: Primary and metastatic carcinoma and meningioma.|
|Reactivity||Bovine, Human, Mouse, Xenopus l|
|Applications||IF, IHC, WB|
|Form||Hybridoma culture supernatant|
|Positive Control||Several human carcinoma cell lines: MCF-7, A-431, HaCaT, CaCo2; bovine cells: MDBK, BMGE|
|References||Cowin, P.et al. (1985). J. Cell Biol. 101: 1442-1454Dockhorn-Dworniczak, B.et al. (1987). Differentiation 35: 53-71Franke, W.W.et al. (1983). Proc. Natl. Acad. Sci., USA, 80: 543-547Moll, R.et al. (1986). Lab. Invest. 54: 4-25Koch, PJ. Et al. (1990) Eur. J. Cell Biol. 53: 1-12Moll, R. et al. (1991) Arch Dermatol Res. 283: 300-309Owaribe, K. et al. (1990) Differentiation 45: 207-220Owaribe, K. et al. (1992) Exp. Cell. Rev 1992: 622-630Schmelz, M. & Franke, WW (1993) Eur. J. Cell Biol. 61: 274-289|
|Intended Use||For Research Use Only|
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