Anti-GDNF Polyclonal Antibody

Antibodies, Polyclonal Antibodies
More Information
Product Name Anti-GDNF Polyclonal Antibody
Description Rabbit IgG polyclonal antibody for Glial cell line-derived neurotrophic factor(GDNF) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background GDNF, Glial cell-derived neurotrophic factor, is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. GDNF is a founding member of the GDNF family of ligands(GFL). The GDNF gene is mapped to human chromosome 5p13.1-p12 by fluorescence in situ hybridization(FISH). This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosisof motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET(rearranged during transfection) protooncogene.
Host Rabbit
Isotype Rabbit IgG
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human GDNF(142-158aa FRYCSGSCDAAETTYDK), different from the related mouse sequence by three amino acids and rat sequence by two amino acids.
Synonyms gdnf antibody, GDNF_HUMAN antibody, Glial cell derived neurotrophic factor antibody, Glial Cell Line Derived Neurotrophic Factor antibody, Glial cell line-derived neurotrophic factor antibody, Glial derived neurotrophic factor antibody, HFB1 GDNF antibody, hGDNF antibody, HSCR3 antibody
Specificity No cross reactivity with other proteins.
Reactivity Predicted to work with: mouse, Rat, Reacts with: human
Applications ICC, IHC, WB
Form Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Uniprot P39905

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