Anti-Human LDL Receptor Polyclonal Antibody

Category: Antibodies
Catalog
03-61099
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Product Name Anti-Human LDL Receptor Polyclonal Antibody
Description The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Synonyms FH, FHC, LDLCQ2
Immunogen Specific synthetic peptide (sequence not conserved in VLDL receptor and LRP) of the LDL receptor extracellular domain (epitope between residues # 184-195, the linker region between repeats 4 and 5)
Specificity The antibody to LDL-R reacts specifically with human LDL-R and is suitable for use in flow cytometry and immunoblotting. First data show that the antibody does not inhibit binding of LDL. In Immunoblotting, the antibody recognizes the 160 kDa band of LDL-R and a 120 kDa band of LDL-R precursor from fibroblasts, hepatocytes, and monocytic cells cultured in the presence of lipoprotein deficient serum.
Reactivity Human
Applications FC, IHC, WB
Form Affinity purified IgG (Immunoaffinity chromatography), in PBS with 0.5% BSA and 0.1% Sodium Azide
Storage 2-8C for immediate use, or at -20C (aliquot)
References Eden ER. et al. (2002) J Clin Invest 110: 1695-1702
Supplier ARP

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